Dynamics of GreB-RNA polymerase interaction allow a proofreading accessory protein to patrol for transcription complexes needing rescue

The secondary channel (SC) of multisubunit RNA polymerases (RNAPs) allows access to the active site and is a nexus for the regulation of transcription. Multiple regulatory proteins bind in the SC and reprogram the catalytic activity of RNAP, but the dynamics of these factors’ interactions with RNAP...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Tetone, Larry E., Friedman, Larry J., Osborne, Melisa L., Ravi, Harini, Kyzer, Scotty, Stumper, Sarah K., Mooney, Rachel A., Landick, Robert, Gelles, Jeff
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320998/
https://ncbi.nlm.nih.gov/pubmed/28137878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616525114
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