Scale up and pharmacokinetic study of a novel mutated chimeric tissue plasminogen activator (mt-PA) in rats

Because of high mortality caused by cardiovascular diseases, various fibrinolytic agents with diverse pharmacokinetic and pharmacodynamic properties have been developed. A novel mutated chimeric tissue plasminogen activator (mt-PA) was developed by the removal of first three domains of t-PA, inserti...

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Pubblicato in:Sci Rep
Autori principali: Raigani, Mozhgan, Rouini, Mohammad-Reza, Golabchifar, Ali-Akbar, Mirabzadeh, Esmat, Vaziri, Behrouz, Barkhordari, Farzaneh, Davami, Fatemeh, Mahboudi, Fereidoun
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5320447/
https://ncbi.nlm.nih.gov/pubmed/28223717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43028
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