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Protein structure guided discovery of functional mutations across 19 cancer types
Local concentrations of mutations are well-known in human cancers. However, their 3-dimensional (3D) spatial relationships have yet to be systematically explored. We developed a computational tool, HotSpot3D, to identify such spatial hotspots (clusters) and to interpret the potential function of var...
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| Τόπος έκδοσης: | Nat Genet |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2016
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5315576/ https://ncbi.nlm.nih.gov/pubmed/27294619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3586 |
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