Lack of impact of pre-existing T97A HIV-1 integrase mutation on integrase strand transfer inhibitor resistance and treatment outcome

T97A is an HIV-1 integrase polymorphism associated with integrase strand transfer inhibitor (INSTI) resistance. Using pooled data from 16 clinical studies, we investigated the prevalence of T97A (pre-existing and emergent) and its impact on INSTI susceptibility and treatment response in INSTI-naive...

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Publicado en:PLoS One
Autores principales: Abram, Michael E., Ram, Renee R., Margot, Nicolas A., Barnes, Tiffany L., White, Kirsten L., Callebaut, Christian, Miller, Michael D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315389/
https://ncbi.nlm.nih.gov/pubmed/28212411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172206
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