Heterogeneous dimer peptide-conjugated polylysine dendrimer-Fe(3)O(4) composite as a novel nanoscale molecular probe for early diagnosis and therapy in hepatocellular carcinoma

A novel nanoscale molecular probe is formulated in order to reduce toxicity and side effects of antitumor drug doxorubicin (DOX) in normal tissues and to enhance the detection sensitivity during early imaging diagnosis. The mechanism involves a specific targeting of Arg-Gly-Asp peptide (RGD)-GX1 het...

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Bibliographic Details
Published in:Int J Nanomedicine
Main Authors: Shen, Jian-Min, Li, Xin-Xin, Fan, Lin-Lan, Zhou, Xing, Han, Ji-Min, Jia, Ming-Kang, Wu, Liang-Fan, Zhang, Xiao-Xue, Chen, Jing
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5315215/
https://ncbi.nlm.nih.gov/pubmed/28243083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S126887
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