The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice

Treatment for chronic constipation in older people is challenging and the condition has a major impact on quality of life. A lack of understanding about the causes of this condition has hampered the development of effective treatments. 5-HT is an important pro-kinetic agent in the colon. We examined...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Patel, Bhavik Anil, Fidalgo, Sara, Wang, Chunfang, Parmar, Leena, Mandona, Kasonde, Panossian, Annabelle, Flint, Melanie S., Ranson, Richard N., Saffrey, M. Jill, Yeoman, Mark S.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309893/
https://ncbi.nlm.nih.gov/pubmed/28198447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42754
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