Inhibition of insulin-like growth factor II (IGF-II)-dependent cell growth by multidentate pentamannosyl 6-phosphate-based ligands targeting the mannose 6-phosphate/IGF-II receptor

The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) binds M6P-capped ligands and IGF-II at different binding sites within the ectodomain and mediates ligand internalization and trafficking to the lysosome. Multivalent M6P-based ligands can cross-bridge the M6P/IGF2R, which inc...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: Zavorka, Megan E., Connelly, Christopher M., Grosely, Rosslyn, MacDonald, Richard G.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308735/
https://ncbi.nlm.nih.gov/pubmed/27694692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11493
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