Phenotypic consequences of somatic mutations in the ataxia-telangiectasia mutated gene in non-small cell lung cancer

Mutations in the Ataxia-telangiectasia mutated (ATM) gene are frequently found in human cancers, including non-small cell lung cancer (NSCLC). Loss of ATM function confers sensitivity to ionising radiation (IR) and topoisomerase inhibitors and may thus define a subset of cancer patients that could g...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Weber, Anika Maria, Drobnitzky, Neele, Devery, Aoife Maire, Bokobza, Sivan Mili, Adams, Richard A., Maughan, Timothy S., Ryan, Anderson Joseph
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2016
Sujets:
Priority Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308618/
https://ncbi.nlm.nih.gov/pubmed/27602502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11845
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