Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA

A new family of (99m)Tc(I)- tricarbonyl complexes and (125)I-heteroaromatic compounds bearing an acridine orange (AO) DNA targeting unit was evaluated for Auger therapy. Characterization of the DNA interaction, performed with the non-radioactive Re and (127)I congeners, confirmed that all compounds...

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Udgivet i:Sci Rep
Main Authors: Pereira, Edgar, do Quental, Letícia, Palma, Elisa, Oliveira, Maria Cristina, Mendes, Filipa, Raposinho, Paula, Correia, Isabel, Lavrado, João, Di Maria, Salvatore, Belchior, Ana, Vaz, Pedro, Santos, Isabel, Paulo, António
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5304164/
https://ncbi.nlm.nih.gov/pubmed/28211920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42544
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