Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells()

Diffuse intrinsic pontine glioma (DIPG) is a devastating disease with an extremely poor prognosis. Recent studies have shown that platelet-derived growth factor receptor (PDGFR) and its downstream effector pathway, PI3K/AKT/mTOR, are frequently amplified in DIPG, and potential therapies targeting th...

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Detalhes bibliográficos
Publicado no:Transl Oncol
Main Authors: Wu, Y. Linda, Maachani, Uday Bhanu, Schweitzer, Melanie, Singh, Ranjodh, Wang, Melinda, Chang, Raymond, Souweidane, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2017
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302185/
https://ncbi.nlm.nih.gov/pubmed/28189993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tranon.2016.12.008
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