A systems approach reveals MAVS signaling in myeloid cells as critical for resistance to Ebola virus in murine models of infection

The unprecedented 2013–16 outbreak of Ebola virus (EBOV) resulted in over 11,300 human deaths. Host resistance to RNA viruses requires RIG-I-like receptor (RLR) signaling through the adaptor protein, mitochondrial antiviral signaling (MAVS), but the role of RLR-MAVS in orchestrating anti-EBOV respon...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Dutta, Mukta, Robertson, Shelly J., Okumura, Atsushi, Scott, Dana P., Chang, Jean, Weiss, Jeffrey M., Sturdevant, Gail L., Feldmann, Friederike, Haddock, Elaine, Chiramel, Abhilash I., Ponia, Sanket S., Dougherty, Jonathan D., Katze, Michael G., Rasmussen, Angela L., Best, Sonja M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289750/
https://ncbi.nlm.nih.gov/pubmed/28099857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.069
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