A systems approach reveals MAVS signaling in myeloid cells as critical for resistance to Ebola virus in murine models of infection

The unprecedented 2013–16 outbreak of Ebola virus (EBOV) resulted in over 11,300 human deaths. Host resistance to RNA viruses requires RIG-I-like receptor (RLR) signaling through the adaptor protein, mitochondrial antiviral signaling (MAVS), but the role of RLR-MAVS in orchestrating anti-EBOV respon...

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書誌詳細
出版年:Cell Rep
主要な著者: Dutta, Mukta, Robertson, Shelly J., Okumura, Atsushi, Scott, Dana P., Chang, Jean, Weiss, Jeffrey M., Sturdevant, Gail L., Feldmann, Friederike, Haddock, Elaine, Chiramel, Abhilash I., Ponia, Sanket S., Dougherty, Jonathan D., Katze, Michael G., Rasmussen, Angela L., Best, Sonja M.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289750/
https://ncbi.nlm.nih.gov/pubmed/28099857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.12.069
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