Sequestration of PRMT1 and Nd1-L mRNA into ALS-linked FUS mutant R521C-positive aggregates contributes to neurite degeneration upon oxidative stress

Mutations in fused in sarcoma (FUS), a DNA/RNA binding protein, are associated with familial amyotrophic lateral sclerosis (ALS). However, little is known about how ALS-causing mutations alter protein-protein and protein-RNA complexes and contribute to neurodegeneration. In this study, we identified...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Jun, Mi-Hee, Ryu, Hyun-Hee, Jun, Yong-Woo, Liu, Tongtong, Li, Yan, Lim, Chae-Seok, Lee, Yong-Seok, Kaang, Bong-Kiun, Jang, Deok-Jin, Lee, Jin-A
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240339/
https://ncbi.nlm.nih.gov/pubmed/28094300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40474
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