Tumor-intrinsic PD-L1 signals regulate cell growth, pathogenesis and autophagy in ovarian cancer and melanoma

PD-L1 antibodies produce efficacious clinical responses in diverse human cancers, but the basis for their effects remains unclear, leaving a gap in understanding of how to rationally leverage the therapeutic activity. PD-L1 is widely expressed in tumor cells but its contributions to tumor pathogenic...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Clark, Curtis A., Gupta, Harshita B., Sareddy, Gangadhara, Pandeswara, Srilakshmi, Lao, Shunhua, Yuan, Bin, Drerup, Justin M., Padron, Alvaro, Conejo-Garcia, José, Murthy, Kruthi, Liu, Yang, Turk, Mary Jo, Thedieck, Kathrin, Hurez, Vincent, Li, Rong, Vadlamudi, Ratna, Curiel, Tyler J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5228566/
https://ncbi.nlm.nih.gov/pubmed/27671674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0258
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