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Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model – Phenytoin and Valproate, Lamotrigine and Valproate

In this study, we investigated the relative efficacy of different classes of commonly used anti-epileptic drugs (AEDs) with different mechanisms of action, individually and in combination, to suppress epileptiform discharges in an in vitro model. Extracellular field potential were recorded in 450 μm...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Taing, Kim Det, O’Brien, Terence J., Williams, David A., French, Chris R.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226812/
https://ncbi.nlm.nih.gov/pubmed/28076384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169974
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