Germline Genetic Variants in TEK, ANGPT1, ANGPT2, MMP9, FGF2 and VEGFA Are Associated with Pathologic Complete Response to Bevacizumab in Breast Cancer Patients

BACKGROUND: We previously reported improved pathologic complete response (pCR) in a prospective phase II study using neoadjuvant bevacizumab in combination with chemotherapy compared to chemotherapy alone in breast cancer patients (41% vs. 25%, p = 0.0291). In this study, we queried germline single-...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Makhoul, Issam, Todorova, Valentina K., Siegel, Eric R., Erickson, Stephen W., Dhakal, Ishwori, Raj, Vinay R., Lee, Jeannette Y., Orloff, Mohammed S., Griffin, Robert J., Henry-Tillman, Ronda S., Klimberg, Suzanne, Hutchins, Laura F., Kadlubar, Susan A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207665/
https://ncbi.nlm.nih.gov/pubmed/28045923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0168550
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