Cartilage biomarkers in the osteoarthropathy of alkaptonuria reveal low turnover and accelerated ageing

Objective. Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polymerizes and deposits in collagenous tissues, leadin...

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Detalhes bibliográficos
Publicado no:Rheumatology (Oxford)
Main Authors: Taylor, Adam M., Hsueh, Ming-Feng, Ranganath, Lakshminarayan R., Gallagher, James A., Dillon, Jane P., Huebner, Janet L., Catterall, Jon B., Kraus, Virginia B.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Basic and Translational Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5188995/
https://ncbi.nlm.nih.gov/pubmed/28028161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/rheumatology/kew355
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