Liver Growth Factor (LGF) Upregulates Frataxin Protein Expression and Reduces Oxidative Stress in Friedreich’s Ataxia Transgenic Mice

Friedreich’s ataxia (FA) is a severe disorder with autosomal recessive inheritance that is caused by the abnormal expansion of GAA repeat in intron 1 of FRDA gen. This alteration leads to a partial silencing of frataxin transcription, causing a multisystem disorder disease that includes neurological...

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Gepubliceerd in:Int J Mol Sci
Hoofdauteurs: Calatrava-Ferreras, Lucía, Gonzalo-Gobernado, Rafael, Reimers, Diana, Herranz, Antonio S., Casarejos, María J., Jiménez-Escrig, Adriano, Regadera, Javier, Velasco-Martín, Juan, Vallejo-Muñoz, Manuela, Díaz-Gil, Juan José, Bazán, Eulalia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5187866/
https://ncbi.nlm.nih.gov/pubmed/27941692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17122066
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