Down-regulation of Krüppel-like factor-4 by microRNA-135a-5p promotes proliferation and metastasis in hepatocellular carcinoma by transforming growth factor-β1

Krüppel-like Factor-4 (KLF4) is a zinc finger transcription factor which plays an important role in cell cycle, proliferation and apoptosis. In Hepatocellular Carcinoma (HCC), the function of KLF4 has been characterized as tumor suppressor. However, the mechanism remains largely unknown. In this stu...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Yao, Shanshan, Tian, Chuan, Ding, Youcheng, Ye, Qingwang, Gao, Yong, Yang, Ning, Li, Qi
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5173156/
https://ncbi.nlm.nih.gov/pubmed/27302923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9934
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