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Selective suppression of the α isoform of p38 MAPK rescues late-stage tau pathology
BACKGROUND: Hyperphosphorylation and aggregation of tau protein are the pathological hallmarks of Alzheimer’s disease and related tauopathies. We previously demonstrated that the microglial activation induces tau hyperphosphorylation and cognitive impairment via activation of p38 mitogen-activated p...
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| Vydáno v: | Alzheimers Res Ther |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BioMed Central
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5157054/ https://ncbi.nlm.nih.gov/pubmed/27974048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0221-y |
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