Elimination of N-glycosylation by site mutation further prolongs the half-life of IFN-α/Fc fusion proteins expressed in Pichia pastoris

BACKGROUND: Interferon (IFN)-α has been commonly used as an antiviral drug worldwide; however, its short half-life in circulation due to its low molecular weight and sensitivity to proteases impacts its efficacy and patient compliance. RESULTS: In this study, we present an IgG1 Fc fusion strategy to...

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Dettagli Bibliografici
Pubblicato in:Microb Cell Fact
Autori principali: Jia, Hao, Guo, Yugang, Song, Xiaoping, Shao, Changsheng, Wu, Jing, Ma, Jiajia, Shi, Mingyang, Miao, Yuhui, Li, Rui, Wang, Dong, Tian, Zhigang, Xiao, Weihua
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142404/
https://ncbi.nlm.nih.gov/pubmed/27927205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-016-0601-9
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