The magnitude of nephron number reduction mediates intrauterine growth-restriction-induced long term chronic renal disease in the rat. A comparative study in two experimental models

BACKGROUND: Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechanism is debated. The aim of this study was to demonstrate that IUGR-induced HT an...

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Vydáno v:J Transl Med
Hlavní autoři: Boubred, Farid, Daniel, Laurent, Buffat, Christophe, Tsimaratos, Michel, Oliver, Charles, Lelièvre-Pégorier, Martine, Simeoni, Umberto
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2016
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5129242/
https://ncbi.nlm.nih.gov/pubmed/27899104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-1086-3
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