Product release is rate-limiting for catalytic processing by the Dengue virus protease

Dengue Virus (DENV) is the most prevalent global arbovirus, yet despite an increasing burden to health care there are currently no therapeutics available to treat infection. A potential target for antiviral drugs is the two-component viral protease NS2B-NS3pro, which is essential for viral replicati...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Shannon, A. E., Pedroso, M. M., Chappell, K. J., Watterson, D., Liebscher, S., Kok, W. M., Fairlie, D. P., Schenk, G., Young, P. R.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5126634/
https://ncbi.nlm.nih.gov/pubmed/27897196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep37539
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