Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation

The reversibility of non-genotoxic phenotypic changes has been explored in order to develop novel preventive and therapeutic approaches for cancer. Quisinostat (JNJ-26481585), a novel second-generation histone deacetylase inhibitor (HDACi), has efficient therapeutic actions on non-small cell lung ca...

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Bibliographic Details
Published in:Cell Biol Toxicol
Main Authors: Bao, Lianmin, Diao, Hua, Dong, Nian, Su, Xiaoqiong, Wang, Bingbin, Mo, Qiongya, Yu, Heguo, Wang, Xiangdong, Chen, Chengshui
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5099365/
https://ncbi.nlm.nih.gov/pubmed/27423454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-016-9347-8
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