High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

Activating NOTCH1 mutations are frequent in human T-cell acute lymphoblastic leukemia (T-ALL) and Notch inhibitors (γ-secretase inhibitors [GSIs]) have produced responses in patients with relapsed, refractory disease. However, sustained responses, although reported, are uncommon, suggesting that oth...

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Dettagli Bibliografici
Pubblicato in:Blood
Autori principali: Chiang, Mark Y., Wang, Qing, Gormley, Anna C., Stein, Sarah J., Xu, Lanwei, Shestova, Olga, Aster, Jon C., Pear, Warren S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2016
Soggetti:
Lymphoid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095757/
https://ncbi.nlm.nih.gov/pubmed/27670423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-692855
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