Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics

Therapeutic manipulation of the gasotransmitter hydrogen sulfide (H(2)S) has recently been proposed as a novel targeted anticancer approach. Here we show that human lung adenocarcinoma tissue expresses high levels of hydrogen sulfide (H(2)S) producing enzymes, namely, cystathionine beta-synthase (CB...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Szczesny, Bartosz, Marcatti, Michela, Zatarain, John R., Druzhyna, Nadiya, Wiktorowicz, John E., Nagy, Péter, Hellmich, Mark R., Szabo, Csaba
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093586/
https://ncbi.nlm.nih.gov/pubmed/27808278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36125
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