Tryptophan Metabolism and Its Relationship with Depression and Cognitive Impairment Among HIV-infected Individuals

OBJECTIVE: Cognitive impairment (CI) and major depressive disorder (MDD) remain prevalent in treated HIV-1 disease; however, the pathogenesis remains elusive. A possible contributing mechanism is immune-mediated degradation of tryptophan (TRP) via the kynurenine (KYN) pathway, resulting in decreased...

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Veröffentlicht in:Int J Tryptophan Res
Hauptverfasser: Keegan, Michael R., Chittiprol, Seetharamaiah, Letendre, Scott L., Winston, Alan, Fuchs, Dietmar, Boasso, Adriano, Iudicello, Jennifer, Ellis, Ronald J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Libertas Academica 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5083113/
https://ncbi.nlm.nih.gov/pubmed/27812290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4137/IJTR.S36464
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