ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis

Arsenic is a mitochondrial toxin, and its derivatives, such as arsenic trioxide (ATO), can trigger endoplasmic reticulum (ER) and the associated unfolded protein response (UPR). Here, we show that arsenic induction of the UPR triggers ATF4, which is involved in regulating this ER-mitochondrial cross...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Arch Biochem Biophys
Prif Awduron: Srivastava, Ritesh K, Li, Changzhao, Ahmad, Aftab, Abrams, Onika, Gorbatyuk, Marina S., Harrod, Kevin S., Wek, Ronald C., Afaq, Farrukh, Athar, Mohammad
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077172/
https://ncbi.nlm.nih.gov/pubmed/27638049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2016.09.003
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