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Terminal Duplex Stability and Nucleotide Identity Differentially Control siRNA Loading and Activity in RNA Interference

Efficient short interfering RNA (siRNA)-mediated gene silencing requires selection of a sequence that is complementary to the intended target and possesses sequence and structural features that encourage favorable functional interactions with the RNA interference (RNAi) pathway proteins. In this stu...

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Vydáno v:Nucleic Acid Ther
Hlavní autoři: Angart, Phillip A., Carlson, Rebecca J., Adu-Berchie, Kwasi, Walton, S. Patrick
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067871/
https://ncbi.nlm.nih.gov/pubmed/27399870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2016.0612
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