Systemic administration of an HIV 1 broadly neutralizing dimeric IgA yields mucosal secretory IgA and virus neutralization

We investigated the mucosal distribution and neutralization potency of rhesus recombinant versions of the HIV-specific, broadly neutralizing antibody b12 (RhB12) following intravenous administration to lactating rhesus monkeys. IgG and dimeric IgA (dIgA) administration resulted in high plasma concen...

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Gepubliceerd in:Mucosal Immunol
Hoofdauteurs: Fouda, Genevieve G., Eudailey, Joshua, Kunz, Erika L., Amos, Joshua D., Liebl, Brooke E., Himes, Jonathan, Boakye-Agyeman, Felix, Beck, Krista, Michaels, Anthony J., Cohen-Wolkowiez, Michael, Haynes, Barton F., Reimann, Keith A., Permar, Sallie R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5063654/
https://ncbi.nlm.nih.gov/pubmed/27072605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2016.32
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