Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models

Experimental and clinical data suggest that pro-angiogenic, pro-inflammatory and mitogenic cytokine leptin can be implicated in ocular neovascularization and other eye pathologies. At least in part, leptin action appears to be mediated through functional interplay with vascular endothelial growth fa...

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Bibliographic Details
Published in:Front Mol Biosci
Main Authors: Coroniti, Roberta, Farjo, Rafal, Nuno, Didier J., Otvos, Laszlo, Scolaro, Laura, Surmacz, Eva
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Molecular Biosciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5062870/
https://ncbi.nlm.nih.gov/pubmed/27790618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2016.00067
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