Amyloid-β 1–24 C-terminal truncated fragment promotes amyloid-β 1–42 aggregate formation in the healthy brain

Substantial data indicate that amyloid-β (Aβ), the major component of senile plaques, plays a central role in Alzheimer’s Disease and indeed the assembly of naturally occurring amyloid peptides into cytotoxic aggregates is linked to the disease pathogenesis. Although Aβ42 is a highly aggregating for...

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Veröffentlicht in:Acta Neuropathol Commun
Hauptverfasser: Mazzitelli, Sonia, Filipello, Fabia, Rasile, Marco, Lauranzano, Eliana, Starvaggi-Cucuzza, Chiara, Tamborini, Matteo, Pozzi, Davide, Barajon, Isabella, Giorgino, Toni, Natalello, Antonino, Matteoli, Michela
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5057504/
https://ncbi.nlm.nih.gov/pubmed/27724899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0381-9
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