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Studies Towards the Improvement of an Anti-Cocaine Monoclonal Antibody for Treatment of Acute Overdose
There is currently no clinically-approved antidote for cocaine overdose. Efforts to develop a therapy via passive immunization have resulted in a human monoclonal antibody, GNCgzk, with a high affinity for cocaine (K(d) = 0.18 nM). Efforts to improve the production of antibody manifolds based on thi...
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| Pubblicato in: | Bioorg Med Chem Lett |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5050165/ https://ncbi.nlm.nih.gov/pubmed/27599743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.08.081 |
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