Studies Towards the Improvement of an Anti-Cocaine Monoclonal Antibody for Treatment of Acute Overdose

There is currently no clinically-approved antidote for cocaine overdose. Efforts to develop a therapy via passive immunization have resulted in a human monoclonal antibody, GNCgzk, with a high affinity for cocaine (K(d) = 0.18 nM). Efforts to improve the production of antibody manifolds based on thi...

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Bibliographic Details
Published in:Bioorg Med Chem Lett
Main Authors: Zhou, Bin, Eubanks, Lisa M, Jacob, Nicholas T, Ellis, Beverly, Roberts, Amanda J, Janda, Kim D
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5050165/
https://ncbi.nlm.nih.gov/pubmed/27599743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.08.081
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