Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice

BACKGROUND & AIMS: Pancreatic stellate cells (PSCs) regulate the development of chronic pancreatitis (CP) and are activated by the cytokine transforming growth factor β (TGFB). Integrins of the αv family promote TGFB signaling in mice, probably by interacting with the Arg-Gly-Asp (RGD) sequence...

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Vydáno v:Cell Mol Gastroenterol Hepatol
Hlavní autoři: Ulmasov, Barbara, Neuschwander-Tetri, Brent A., Lai, Jinping, Monastyrskiy, Vladimir, Bhat, Trisha, Yates, Matthew P., Oliva, Jonathan, Prinsen, Michael J., Ruminski, Peter G., Griggs, David W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2016
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5042566/
https://ncbi.nlm.nih.gov/pubmed/28174730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2016.03.004
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