The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8(+) T-cell responses: The immunological consequences of the biodistribution profile

A prerequisite for vaccine-mediated induction of CD8(+) T-cell responses is the targeting of dendritic cell (DC) subsets specifically capable of cross-presenting antigen epitopes to CD8(+) T cells. Administration of a number of cationic adjuvants via the intraperitoneal (i.p.) route has been shown t...

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Detalhes bibliográficos
Publicado no:J Control Release
Principais autores: Schmidt, Signe Tandrup, Khadke, Swapnil, Korsholm, Karen Smith, Perrie, Yvonne, Rades, Thomas, Andersen, Peter, Foged, Camilla, Christensen, Dennis
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Publishers 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041310/
https://ncbi.nlm.nih.gov/pubmed/27574990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.08.034
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