Metformin inhibits development of diabetic retinopathy through inducing alternative splicing of VEGF-A

Previous studies have shown that metformin, an AMP-activated protein kinase activator widely prescribed for type 2 diabetes, is especially beneficial in cases of diabetic retinopathy (DR) with undetermined mechanisms. Here, we used a streptozotocin-induced diabetes model in mice to study the effects...

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Veröffentlicht in:Am J Transl Res
Hauptverfasser: Yi, Quan-Yong, Deng, Gang, Chen, Nan, Bai, Zhi-Sha, Yuan, Jian-Shu, Wu, Guo-Hai, Wang, Yu-Wen, Wu, Shan-Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040692/
https://ncbi.nlm.nih.gov/pubmed/27725874
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