Crystal Structure of the Metallo-β-Lactamase GOB in the Periplasmic Dizinc Form Reveals an Unusual Metal Site

Metallo-beta-lactamases (MBLs) are broad-spectrum, Zn(II)-dependent lactamases able to confer resistance to virtually every β-lactam antibiotic currently available. The large diversity of active-site structures and metal content among MBLs from different sources has limited the design of a pan-MBL i...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Morán-Barrio, Jorgelina, Lisa, María-Natalia, Larrieux, Nicole, Drusin, Salvador I., Viale, Alejandro M., Moreno, Diego M., Buschiazzo, Alejandro, Vila, Alejandro J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5038331/
https://ncbi.nlm.nih.gov/pubmed/27458232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01067-16
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