Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival

TBC1D10C is a protein previously demonstrated to bind and inhibit Ras and Calcineurin. In cardiomyocytes, also CaMKII is inhibited and all three targeted enzymes are known to promote maladaptive cardiomyocyte hypertrophy. Here, in accordance with lack of Calcineurin inhibition in vivo, we did not ob...

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Publicat a:Sci Rep
Autors principals: Volland, Cornelia, Bremer, Sebastian, Hellenkamp, Kristian, Hartmann, Nico, Dybkova, Nataliya, Khadjeh, Sara, Kutschenko, Anna, Liebetanz, David, Wagner, Stefan, Unsöld, Bernhard, Didié, Michael, Toischer, Karl, Sossalla, Samuel, Hasenfuß, Gerd, Seidler, Tim
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036039/
https://ncbi.nlm.nih.gov/pubmed/27667030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33853
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