Enhanced cardiac TBC1D10C expression lowers heart rate and enhances exercise capacity and survival

TBC1D10C is a protein previously demonstrated to bind and inhibit Ras and Calcineurin. In cardiomyocytes, also CaMKII is inhibited and all three targeted enzymes are known to promote maladaptive cardiomyocyte hypertrophy. Here, in accordance with lack of Calcineurin inhibition in vivo, we did not ob...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Volland, Cornelia, Bremer, Sebastian, Hellenkamp, Kristian, Hartmann, Nico, Dybkova, Nataliya, Khadjeh, Sara, Kutschenko, Anna, Liebetanz, David, Wagner, Stefan, Unsöld, Bernhard, Didié, Michael, Toischer, Karl, Sossalla, Samuel, Hasenfuß, Gerd, Seidler, Tim
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5036039/
https://ncbi.nlm.nih.gov/pubmed/27667030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep33853
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