Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis

Telomeres are short in type II alveolar epithelial cells (AECs) of patients with idiopathic pulmonary fibrosis (IPF). Whether dysfunctional telomeres contribute directly to development of lung fibrosis remains unknown. The objective of this study was to investigate whether telomere dysfunction in ty...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Naikawadi, Ram P., Disayabutr, Supparerk, Mallavia, Benat, Donne, Matthew L., Green, Gary, La, Janet L., Rock, Jason R., Looney, Mark R., Wolters, Paul J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033906/
https://ncbi.nlm.nih.gov/pubmed/27699234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86704
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