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Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis

Telomeres are short in type II alveolar epithelial cells (AECs) of patients with idiopathic pulmonary fibrosis (IPF). Whether dysfunctional telomeres contribute directly to development of lung fibrosis remains unknown. The objective of this study was to investigate whether telomere dysfunction in ty...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Naikawadi, Ram P., Disayabutr, Supparerk, Mallavia, Benat, Donne, Matthew L., Green, Gary, La, Janet L., Rock, Jason R., Looney, Mark R., Wolters, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5033906/
https://ncbi.nlm.nih.gov/pubmed/27699234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86704
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