Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE

Cancer invasion is a hallmark of metastasis. The mesenchymal mode of cancer cell invasion is mediated by elongated membrane protrusions driven by the assembly of branched F-actin networks. How deregulation of actin regulators promotes cancer cell invasion is still enigmatic. We report that increased...

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Publicat a:Oncogene
Autors principals: Carmona, G, Perera, U, Gillett, C, Naba, A, Law, A-L, Sharma, V P, Wang, J, Wyckoff, J, Balsamo, M, Mosis, F, De Piano, M, Monypenny, J, Woodman, N, McConnell, R E, Mouneimne, G, Van Hemelrijck, M, Cao, Y, Condeelis, J, Hynes, R O, Gertler, F B, Krause, M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031503/
https://ncbi.nlm.nih.gov/pubmed/26996666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.47
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