MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer

Hypoxia and dysregulation of microRNAs (miRNAs) have been identified as crucial factors in carcinogenesis. However, the potential mechanisms of HIF-1α and miR-421 in gastric cancer have not been well elucidated. In this study, we found that miR-421 was up-regulated by HIF-1α. Overexpression of miR-4...

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Udgivet i:Oncotarget
Main Authors: Ge, Xiaoxiao, Liu, Xinyang, Lin, Fengjuan, Li, Peng, Liu, Kaiyi, Geng, Ruixuan, Dai, Congqi, Lin, Ying, Tang, Wenbo, Wu, Zheng, Chang, Jinjia, Lu, Jianwei, Li, Jin
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5029715/
https://ncbi.nlm.nih.gov/pubmed/27016414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8228
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