Ablation of the Thiol Transferase Glutaredoxin-1 Augments Protein S-Glutathionylation and Modulates Type 2 Inflammatory Responses and IL-17 in a House Dust Mite Model of Allergic Airway Disease in Mice

S-glutathionylation has emerged as an oxidant-induced post-translational modification of protein cysteines that affects structure and function. The oxidoreductase glutaredoxin-1 (Glrx1), under physiological conditions, catalyzes deglutathionylation and restores the protein thiol group. The involveme...

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Publicado en:Ann Am Thorac Soc
Main Authors: Hoffman, Sidra M., Nolin, James D., Jones, Jane T., Lahue, Karolyn G., Chapman, David G., Aliyeva, Minara, Daphtary, Nirav, Lundblad, Lennart K. A., Abdalla, Sarah, Ather, Jennifer L., Ho, Ye-Shih, Irvin, Charles G., Anathy, Vikas, Wouters, Emiel F. M., Poynter, Matthew E., Janssen-Heininger, Yvonne M. W.
Formato: Artigo
Idioma:Inglês
Publicado: American Thoracic Society 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5015743/
https://ncbi.nlm.nih.gov/pubmed/27027965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1513/AnnalsATS.201510-656MG
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