C5a Induces the Synthesis of IL-6 and TNF-α in Rat Glomerular Mesangial Cells through MAPK Signaling Pathways

Inflammatory response has been reported to contribute to the renal lesions in rat Thy-1 nephritis (Thy-1N) as an animal model of human mesangioproliferative glomerulonephritis (MsPGN). Besides C5b-9 complex, C5a is also a potent pro-inflammatory mediator and correlated to severity of various nephrit...

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Vydáno v:PLoS One
Hlavní autoři: Ji, Mingde, Lu, Yanlai, Zhao, Chenhui, Gao, Wenxing, He, Fengxia, Zhang, Jing, Zhao, Dan, Qiu, Wen, Wang, Yingwei
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5008626/
https://ncbi.nlm.nih.gov/pubmed/27583546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0161867
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