Dose Optimization for Single Intradiscal Administration of the Tumor Necrosis Factor-α Inhibitor, Etanercept, in Rat Disc Injury Models

STUDY DESIGN: Experimental animal study. PURPOSE: We aimed to determine the optimal dose of a single direct injection of the tumor necrosis factor (TNF)-α inhibitor, etanercept, by using the rat model of degenerative intervertebral disc from injury. OVERVIEW OF LITERATURE: The pain-related peptide e...

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Bibliographic Details
Published in:Asian Spine J
Main Authors: Inage, Kazuhide, Orita, Sumihisa, Yamauchi, Kazuyo, Suzuki, Takane, Suzuki, Miyako, Sakuma, Yoshihiro, Kubota, Go, Oikawa, Yasuhiro, Sainoh, Takeshi, Sato, Jun, Fujimoto, Kazuki, Shiga, Yasuhiro, Abe, Koki, Kanamoto, Hirohito, Inoue, Masahiro, Kinoshita, Hideyuki, Takahashi, Kazuhisa, Ohtori, Seiji
Format: Artigo
Language:Inglês
Published: Korean Society of Spine Surgery 2016
Subjects:
Basic Study
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995242/
https://ncbi.nlm.nih.gov/pubmed/27559439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4184/asj.2016.10.4.619
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