Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice

Milk fat globule-EGF factor 8 (MFG-E8) maintains the intestinal homeostasis by enhancing enterocyte migration and attenuating inflammation. We previously reported that sepsis is associated with down-regulation of intestinal MFG-E8 and impairment of enterocyte migration. Here, we showed that impairme...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Wang, Xiao, Hao, Liangliang, Bu, Heng-Fu, Scott, Alexander W., Tian, Ke, Liu, Fangyi, De Plaen, Isabelle G., Liu, Yulan, Mirkin, Chad A., Tan, Xiao-Di
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990839/
https://ncbi.nlm.nih.gov/pubmed/27538453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31687
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