Role of EZH2 histone methyltrasferase in melanoma progression and metastasis

There is accumulating evidence that the histone methyltransferase enhancer of zeste homolog 2 (EZH2), the main component of the polycomb-repressive complex 2 (PRC2), is involved in melanoma progression and metastasis. Novel drugs that target and reverse such epigenetic changes may find a way into th...

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Bibliographic Details
Published in:Cancer Biol Ther
Main Authors: Mahmoud, Fade, Shields, Bradley, Makhoul, Issam, Hutchins, Laura F., Shalin, Sara C., Tackett, Alan J.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4990393/
https://ncbi.nlm.nih.gov/pubmed/27105109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1167291
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