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3D QSAR, pharmacophore and molecular docking studies of known inhibitors and designing of novel inhibitors for M18 aspartyl aminopeptidase of Plasmodium falciparum

BACKGROUND: The Plasmodium falciparum M18 Aspartyl Aminopeptidase (PfM18AAP) is only aspartyl aminopeptidase which is found in the genome of P. falciparum and is essential for its survival. The PfM18AAP enzyme performs various functions in the parasite and the erythrocytic host such as hemoglobin di...

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Detalles Bibliográficos
Publicado en:BMC Struct Biol
Autores principales: Kumari, Madhulata, Chandra, Subhash, Tiwari, Neeraj, Subbarao, Naidu
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4989538/
https://ncbi.nlm.nih.gov/pubmed/27534744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12900-016-0063-7
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